MBL2, mannose binding lectin 2, 4153

N. diseases: 563; N. variants: 21
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3280586
Disease: Mannose-Binding Protein Deficiency
Mannose-Binding Protein Deficiency 		0.700 Biomarker disease GENOMICS_ENGLAND Long-term Clinical Outcome of Antibody Replacement Therapy in Humoral Immunodeficient Adults With Respiratory Tract Infections. 28347655 2017
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.310 Biomarker disease PSYGENET Bipolar disorder was associated with the MBL2 LXPA haplotype and lower MASP-2 levels. 24856568 2014
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive 		0.100 Biomarker disease HPO
CUI: C1853193
Disease: Recurrent skin infections
Recurrent skin infections 		0.100 Biomarker phenotype HPO
CUI: C1970263
Disease: Recurrent meningococcal disease
Recurrent meningococcal disease 		0.100 Biomarker phenotype HPO
CUI: C4021751
Disease: Recurrent Klebsiella infections
Recurrent Klebsiella infections 		0.100 Biomarker phenotype HPO
CUI: C4703487
Disease: Disseminated cryptosporidium infection
Disseminated cryptosporidium infection 		0.100 Biomarker disease HPO
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.400 Biomarker group LHGDN Thus, the notably diverse patterns of MBL responses among patients with different clinical courses and treatments suggest that MBL and complement activation by the MBL pathway could be involved in the pathophysiology of HIV infection. 12640191 2003
CUI: C0019693
Disease: HIV Infections
HIV Infections 		0.400 GeneticVariation group LHGDN We have analysed the association of mbl-2 structural and promoter polymorphisms with HIV infection and tuberculosis (TBC) in a white Spanish population, including 615 HIV patients with and without TBC, 127 no-HIV TBC patients, 142 TBC household contacts and 344 controls. 16500704 2006
CUI: C3714514
Disease: Infection
Infection 		0.400 Biomarker group LHGDN Mannose-binding lectin and mannose-binding lectin-associated serine protease 2 in susceptibility, severity, and outcome of pneumonia in adults. 18582923 2008
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN Mannose-binding lectin variant associated with severe malaria in young African children. 18396436 2008
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN [Relationship between the gene mutations of mannose binding protein and the progression of hepatitis B infection]. 18543229 2008
CUI: C3714514
Disease: Infection
Infection 		0.400 Biomarker group LHGDN Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis. 16115848 2005
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN Influence of mannose-binding lectin on HIV infection and tuberculosis in a Western-European population. 16500704 2006
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN Mannose-binding lectin MBL2 gene polymorphisms and outcome of hepatitis C virus-infected patients. 18592362 2008
CUI: C3714514
Disease: Infection
Infection 		0.400 AlteredExpression group LHGDN Mannose-binding lectin and susceptibility to infection in Chinese patients with systemic lupus erythematosus. 17552055 2007
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN Mannose-binding lectin haplotypes may be associated with cerebral palsy only after perinatal viral exposure. 18455525 2008
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN Association between MBL2 gene functional polymorphisms and high-risk human papillomavirus infection in Brazilian women. 18486762 2008
CUI: C3714514
Disease: Infection
Infection 		0.400 Biomarker group LHGDN Mannose-binding lectin in severe acute respiratory syndrome coronavirus infection. 15838797 2005
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN The influence of innate immunity gene receptors polymorphisms in renal transplant infections. 17565323 2007
CUI: C3714514
Disease: Infection
Infection 		0.400 GeneticVariation group LHGDN Mannose-binding lectin gene polymorphisms and hepatitis B virus infection in Vietnamese patients. 12517417 2003
CUI: C3714514
Disease: Infection
Infection 		0.400 Biomarker group LHGDN Mannose-binding lectin and maladies of the bowel and liver. 17072973 2006
CUI: C0085207
Disease: Gestational Diabetes
Gestational Diabetes 		0.320 GeneticVariation phenotype LHGDN In conclusion, pregnant women bearing the G54D MBL allele have a greater risk for developing GDM and having heavier infants. 15472209 2004
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 AlteredExpression disease LHGDN Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls. 17610322 2007
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.100 AlteredExpression disease LHGDN S-nitrosylation of mannose binding lectin regulates its functional activities and the formation of autoantibody in rheumatoid arthritis. 18348874 2008